Highlighted Publications
Letchworth R#, Tanaka M#, Barnes AA, Lum L, Hughes S, Schlauderaff G, Chaudhary P, Ng KM, Superville D, Leek J, Tay J, Martinez Luna C, Gonzalez M, Smith E, Deacon DC, Grossman A, Reeves MQ. CIT tumor lines: A novel series of immunogenic cutaneous squamous cell carcinoma cell lines derived from chemical carcinogenesis. Bioxiv, doi: 10.1101/2025.04.03.647071 (2025). (PMID: 40291731 / PMCID: PMC12026586)
#Authors contributed equally
Tanaka M, Lum L, Hu K, Chaudhary P, Hughes S, Ledezma-Soto C, Samad B, Superville D, Ng K, Chumber A, Benson C, Adams Z, Kersten K, Aguilar OA, Fong L, Combes AJ, Krummel MF, Reeves MQ. Tumor cell heterogeneity drives spatial organization of the intratumoral immune response. Journal of Experimental Medicine 222, e20242282 (2025). (PMID: 40167599 / PMCID: PMC11960709)
Reeves MQ. Mapping the transcriptional evolution of human metastatic breast cancer. J Clin Invest 134, e183971 (2024). (PMID: 39225091 / PMCID: PMC11364401)
Reeves MQ* & Balmain A. Mutations, Bottlenecks, and Clonal Sweeps: How Environmental Carcinogens and Genomic Changes Shape Clonal Evolution during Tumor Progression. Cold Spring Harb Perspect Med 14, a041388 (2024). (PMID: 38052482)
*Co-corresponding author
Reeves MQ*, Kandyba E, Harris S, Del Rosario R, Balmain A. Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis. Nat. Cell Bio. 20, 699-709 (2018). (PMID: 29802408 / PMCID: PMC6400587)
*Co-corresponding author
More Publications From Melissa Reeves
Li Y, Kandyba E, Halliwill K, Delrosario R, Tran Q, Bayani N, Wu D, Mirzoeva O, Reeves MQ, Islam M, Riva L, Bergstrom E, Achanta K, DiGiovanni J, Alexandrob L, Balmain A. Long term latency of highly mutated cells in normal mouse skin is reversed by exposure to tumor promoters and chronic tissue damage Cancer Discovery 15:1115-1128 (2025).
Greiner D, Xue Q, Waddell TQA, Kurudza E, Chaudhary P, Belote RL, Dotti G, Judson-Torres RL, Reeves MQ, Cheshier SH, Roh-Johnson M. Human CSPG4-targeting CAR-macrophages inhibit melanoma growth Oncogene 44: 1665-1677 (2025).
Zhang Y, Urquijo MA, Zitnay RG, Marks K, Belote RL, Hansen MMK, Ferita M, Neuendorf H, Liu T, Smith EA, Mehrabad EM, Hejna M, Moustafa TE, Lange D, Hu M, Vand-Rajabpour F, Done A, Becker CA, Lieberman M, Chang M, Lohman BK, Stubben CJ, Reeves MQ, Zhang X, Weinberg LS, VanBrocklin MW, Deacon DC, Grossman D, Spike BT, Lex A, Boyle GM, Kulkarni R, Zangle T, Judson-Torres RL. A BRN2:MYC Transcriptional Axis Regulates Interconversion Between Therapy Resistant and Tumorigenic Phenotypes in Melanoma Cell Reports, (2025).
Wang J, Xu Z, Xu L, Wang L, Geng J, Wang X, Xu M, Superville D, Reeves M, Evert M, Calvisi DF, Chen X, Song X. Uncoupling Metastasis and Epithelial-to-mesenchymal transition in sgP19/kRAS-Driven Spontaneous Metastatic Liver Tumor Model. Advanced Science, e14198 (2025).
Fitch B, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Kogan SC. Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia. Blood Advances 6, 854-865 (2022). (PMID: 34727170 / PMCID: PMC8945291)
Wang H, Song X, Liao H, Wang P, Zhang Y, Che L, Zhang J, Zhou Y, Cigliano A, Ament C, Superville D, Ribback S, Reeves M, Pes GM, Liang B, Wu H, Evert M, Calvisi DF, Zeng Y, Chen X. Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans. Hepatology, 74, 248-263 (2021). (PMID: 33368437 / PMCID: PMC8222417)
Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ. α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas. J. Immunother. Cancer 7, 62 (2019). (PMID: 30832732 / PMCID: PMC6399967)
Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery (Reeves) MQ, Del Rosario R, Kang HC, Wong CE, Seibler J, Beuger V, Pellegrino M, Sciambi A, Eastburn DJ, Balmain A. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Nat. Gen. 49, 1624-31 (2017). (PMID: 28945253 / PMCID: PMC5662105)
McCreery MQ* and Balmain A. Chemical carcinogenesis models of cancer: Back to the future. Ann. Rev. Cancer Bio. 1, 295-312 (2017).
*Co-corresponding author
McCreery MQ, Halliwill KD, Chin D, et al. Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. Nat. Med. 21, 1514–20 (2015). (PMID: 26523969 / PMCID: PMC5094808)
Smith CC, Lasater EA, Lin KC, Wang Q, McCreery MQ et al. Crenolanib is a selective type I pan-FLT3 inhibitor. Proc Natl Acad Sci U S A 111, 5319–24 (2014). (PMID: 24623852 / PMCID: PMC3986131)
Rudolph M, McCreery MQ, et al. High chemoselectivity in phenol synthesis. Beilstein J. Org. Chem. 7, 794-801 (2011). (PMID: 21804874 / PMCID: PMC3135103)